S-ribosylhomocysteine lyase

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In enzymology, a S-ribosylhomocysteine lyase (EC is an enzyme that catalyzes the chemical reaction

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione

Hence, this enzyme has one substrate, S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, and two products, L-homocysteine and (4S)-4,5-dihydroxypentan-2,3-dione.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]. Other names in common use include S-ribosylhomocysteinase, and LuxS. This enzyme participates in methionine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1JQW, 2FQO, and 2FQT.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Zhu J, Dizin E, Hu X, Wavreille AS, Park J, Pei D (2003). "S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein". Biochemistry. 42: 4717&ndash, 26. PMID 12705835.
  • Miller MB, Bassler BL (2001). "Quorum sensing in bacteria". Annu. Rev. Microbiol. 55: 165&ndash, 99. PMID 11544353.

External links

The CAS registry number for this enzyme class is 37288-63-4.

Gene Ontology (GO) codes