This article provides insufficient context for those unfamiliar with the subject.Learn how and when to remove this template message)(
This is a highly conserved enzyme contained in many bacteria, including Mycobacterium tuberculosis. It is the target of the antibiotic, Rifampicin. A gene probe for rpoB can detect mutations in the gene that confer rifampicin resistance.
It was initially discovered that resistance to Rifampicin in M. tuberculosis strains was caused by a single point mutation in the rpoB gene. However, recent studies have shown that multiple rpoB mutations in different codons of rpoB can occur.
- rpoB+protein,+Mycobacterium+tuberculosis at the US National Library of Medicine Medical Subject Headings (MeSH)
|60x45px||This enzyme-related article is a stub. You can help Wikipedia by expanding it.|
|40x30px||This genetics article is a stub. You can help Wikipedia by expanding it.|