Roxatidine

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Roxatidine acetate
Systematic (IUPAC) name
2-oxo-2-(3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino)ethyl acetate
Identifiers
CAS number 78628-28-1
ATC code A02BA06
PubChem 5105
DrugBank DB08806
Chemical data
Formula C19H28N2O4 
Mol. mass 348.437 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability 80–90%
Protein binding 5–7%
Metabolism Hepatic deacetylation
Minor involvement of CYP2D6 and CYP2A6
Half life 5–7 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes Oral

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Roxatidine acetate is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.[1][2]

Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.[1]

It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece and South Africa.[2]

References



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