Rosmarinate synthase

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In enzymology, a rosmarinate synthase (EC is an enzyme that catalyzes the chemical reaction

caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate CoA + rosmarinate

Thus, the two substrates of this enzyme are caffeoyl-CoA and 3-(3,4-dihydroxyphenyl)lactate, whereas its two products are CoA and rosmarinate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase. Other names in common use include rosmarinic acid synthase, caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid, caffeoyltransferase, and 4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase. This enzyme participates in tyrosine metabolism.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
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  • Google Scholar references for
  • Petersen M and Alfermann AW (1988). "Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase". Z. Naturforsch. C: Biosci. 43: 501&ndash, 504.

External links

The CAS registry number for this enzyme class is 117590-80-4.

Gene Ontology (GO) codes