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In enzymology, a rhamnulokinase (EC is an enzyme that catalyzes the chemical reaction

ATP + L-rhamnulose ADP + L-rhamnulose 1-phosphate

Thus, the two substrates of this enzyme are ATP and L-rhamnulose, whereas its two products are ADP and L-rhamnulose 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:L-rhamnulose 1-phosphotransferase. Other names in common use include RhuK, rhamnulokinase (phosphorylating), L-rhamnulokinase, L-rhamnulose kinase, and rhamnulose kinase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2CGJ, 2CGK, 2CGL, and 2UYT.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Wilson DM and Ajl S (1957). "Metabolism of L-rhamnose by Escherichia coli. II. The phosphorylation of L-rhamnulose". J. Bacteriol. 73: 415&ndash, 420.

External links

The CAS registry number for this enzyme class is 9030-52-8.

Gene Ontology (GO) codes