Rathke's pouch

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Rathke's pouch
Gray982.png
Sketches in profile of two stages in the development of the human digestive tube.
Gray's subject #275 1277
Carnegie stage 10
Gives rise to anterior pituitary
Dorlands/Elsevier p_31/12662673

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Overview

In embryogenesis, Rathke's pouch is a depression in the roof of the developing mouth in front of the buccopharyngeal membrane. It gives rise to the anterior pituitary, a part of the endocrine system.

Development

The pouch eventually loses its connection with the pharynx giving rise to the anterior pituitary. The anterior wall of Rathke's pouch proliferates, filling most of the pouch to form pars distalis and pars tuberalis. The posterior wall forms pars intermedia.

In some organisms (humans being a notable exception), the proliferating anterior wall does not fully occupy Rathke's pouch, leaving a remnant (Rathke's cleft) between the pars distalis and pars intermedia.

Clinical significance

Rathke's pouch may also persist as cysts (craniopharyngioma) within the pars intermedia.

Eponym

It is named for Martin Rathke.[1][2]

References

  1. synd/3564 at Who Named It
  2. M. H. Rathke. Entwicklungsgeschichte der Natter (Coluber natrix). Königsberg, Bornträger, 1839.

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