CD151

(Redirected from Raph antigen system)
Jump to: navigation, search
CD151 molecule (Raph blood group)
Identifiers
Symbol(s) CD151; GP27; MER2; PETA-3; RAPH; SFA1; TSPAN24
External IDs OMIM: 602243 MGI1096360 Homologene20916
RNA expression pattern

File:PBB GE CD151 204306 s at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 977 12476
Ensembl ENSG00000177697 ENSMUSG00000025510
Uniprot P48509 Q921J7
Refseq NM_001039490 (mRNA)
NP_001034579 (protein)
NM_009842 (mRNA)
NP_033972 (protein)
Location Chr 11: 0.82 - 0.83 Mb Chr 7: 141.32 - 141.32 Mb
Pubmed search [1] [2]

WikiDoc Resources for CD151

Articles

Most recent articles on CD151

Most cited articles on CD151

Review articles on CD151

Articles on CD151 in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on CD151

Images of CD151

Photos of CD151

Podcasts & MP3s on CD151

Videos on CD151

Evidence Based Medicine

Cochrane Collaboration on CD151

Bandolier on CD151

TRIP on CD151

Clinical Trials

Ongoing Trials on CD151 at Clinical Trials.gov

Trial results on CD151

Clinical Trials on CD151 at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on CD151

NICE Guidance on CD151

NHS PRODIGY Guidance

FDA on CD151

CDC on CD151

Books

Books on CD151

News

CD151 in the news

Be alerted to news on CD151

News trends on CD151

Commentary

Blogs on CD151

Definitions

Definitions of CD151

Patient Resources / Community

Patient resources on CD151

Discussion groups on CD151

Patient Handouts on CD151

Directions to Hospitals Treating CD151

Risk calculators and risk factors for CD151

Healthcare Provider Resources

Symptoms of CD151

Causes & Risk Factors for CD151

Diagnostic studies for CD151

Treatment of CD151

Continuing Medical Education (CME)

CME Programs on CD151

International

CD151 en Espanol

CD151 en Francais

Business

CD151 in the Marketplace

Patents on CD151

Experimental / Informatics

List of terms related to CD151

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]


CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[1]


The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[1]

See also

References

Further reading

  • Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye.". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647. 
  • Ashman LK (2003). "CD151.". J. Biol. Regul. Homeost. Agents. 16 (3): 223–6. PMID 12456024. 
  • Ashman LK, Aylett GW, Mehrabani PA; et al. (1992). "The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen.". Br. J. Haematol. 79 (2): 263–70. PMID 1958484. 
  • Fitter S, Tetaz TJ, Berndt MC, Ashman LK (1995). "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3.". Blood. 86 (4): 1348–55. PMID 7632941. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. PMID 8125298. 
  • Hasegawa H, Utsunomiya Y, Kishimoto K; et al. (1996). "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily.". J. Virol. 70 (5): 3258–63. PMID 8627808. 
  • Hasegawa H, Kishimoto K, Yanagisawa K; et al. (1997). "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization.". Genomics. 40 (1): 193–6. PMID 9070943. doi:10.1006/geno.1996.4563. 
  • Sincock PM, Mayrhofer G, Ashman LK (1997). "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin.". J. Histochem. Cytochem. 45 (4): 515–25. PMID 9111230. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. PMID 9373149. 
  • Fitter S, Seldin MF, Ashman LK (1998). "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms.". Biochim. Biophys. Acta. 1398 (1): 75–85. PMID 9602068. 
  • Sincock PM, Fitter S, Parton RG; et al. (1999). "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function.". J. Cell. Sci. 112 ( Pt 6): 833–44. PMID 10036233. 
  • Serru V, Le Naour F, Billard M; et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.". Biochem. J. 340 ( Pt 1): 103–11. PMID 10229664. 
  • Testa JE, Brooks PC, Lin JM, Quigley JP (1999). "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis.". Cancer Res. 59 (15): 3812–20. PMID 10447000. 
  • Sterk LM, Geuijen CA, Oomen LC; et al. (2000). "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.". J. Cell Biol. 149 (4): 969–82. PMID 10811835. 
  • Whittock NV, McLean WH (2001). "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene.". Biochem. Biophys. Res. Commun. 281 (2): 425–30. PMID 11181065. doi:10.1006/bbrc.2001.4384. 
  • Charrin S, Le Naour F, Oualid M; et al. (2001). "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.". J. Biol. Chem. 276 (17): 14329–37. PMID 11278880. doi:10.1074/jbc.M011297200. 
  • Suzuki Y, Tsunoda T, Sese J; et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes.". Genome Res. 11 (5): 677–84. PMID 11337467. doi:10.1101/gr.164001. 
  • Kohno M, Hasegawa H, Miyake M; et al. (2002). "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase.". Int. J. Cancer. 97 (3): 336–43. PMID 11774285. 
  • Zhang XA, Kazarov AR, Yang X; et al. (2002). "Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis.". Mol. Biol. Cell. 13 (1): 1–11. PMID 11809818. doi:10.1091/mbc.01-10-0481. 
</dl>

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Linked-in.jpg