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Template:Infobox gene CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[1]


The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[1]


File:Fibrosarcoma cells CD151.jpg
Fibrosarcoma cells, reportedly stained with an antibody binding to CD151 (green) and a dye for the nucleus (blue).

CD151 has been shown to interact with CD46.[2]

See also


  1. 1.0 1.1 "Entrez Gene: CD151 CD151 molecule (Raph blood group)". 
  2. Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. PMID 10741407. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.