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Ribosomal protein L7a
Symbols RPL7A ; SURF3; TRUP
External IDs OMIM: 185640 MGI3649050 HomoloGene88345

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 6130
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 545512


    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_000972 (mRNA)
NP_000963 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |XM_619886 (mRNA)
XP_619886 (protein)



    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Ribosomal protein L7a, also known as RPL7A, is a human gene.[1]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[1]


  1. 1.0 1.1 "Entrez Gene: RPL7A ribosomal protein L7a".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. PMID 8722009.
  • Colombo P, Fried M (1992). "Functional elements of the ribosomal protein L7a (rpL7a) gene promoter region and their conservation between mammals and birds". Nucleic Acids Res. 20 (13): 3367–73. PMID 1630908.
  • Ben-Ishai R, Scharf R, Sharon R, Kapten I (1990). "A human cellular sequence implicated in trk oncogene activation is DNA damage inducible". Proc. Natl. Acad. Sci. U.S.A. 87 (16): 6039–43. PMID 1696715.
  • Colombo P, Yon J, Fried M (1992). "The organization and expression of the human L7a ribosomal protein gene". Biochim. Biophys. Acta. 1129 (1): 93–5. PMID 1756182.
  • Ziemiecki A, Müller RG, Fu XC; et al. (1990). "Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a". EMBO J. 9 (1): 191–6. PMID 2403926.
  • Kozma SC, Redmond SM, Fu XC; et al. (1988). "Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences". EMBO J. 7 (1): 147–54. PMID 2966065.
  • Burris TP, Nawaz Z, Tsai MJ, O'Malley BW (1995). "A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9525–9. PMID 7568167.
  • Qu LH, Henry Y, Nicoloso M; et al. (1995). "U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA". Nucleic Acids Res. 23 (14): 2669–76. PMID 7651828.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Seshadri T, Uzman JA, Oshima J, Campisi J (1993). "Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene". J. Biol. Chem. 268 (25): 18474–80. PMID 8360149.
  • De Falco S, Russo G, Angiolillo A, Pietropaolo C (1993). "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene". Gene. 126 (2): 227–35. PMID 8482538.
  • Yon J, Jones T, Garson K; et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. PMID 8499913.
  • Nicoloso M, Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J. Mol. Biol. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID 8764399.
  • Mor O, Duhig T, Fried M (1996). "A high frequency polymorphism in the candidate region for tuberous sclerosis 1 (TSC1) at 9q34". Ann. Hum. Genet. 60 (Pt 3): 259–60. PMID 8800442.
  • Russo G, Ricciardelli G, Pietropaolo C (1997). "Different domains cooperate to target the human ribosomal L7a protein to the nucleus and to the nucleoli". J. Biol. Chem. 272 (8): 5229–35. PMID 9030593.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Kenmochi N, Kawaguchi T, Rozen S; et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. PMID 9582194.
  • Gilley J, Fried M (1998). "Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants". DNA Cell Biol. 17 (7): 591–602. PMID 9703018.
  • Lalli E, Ohe K, Hindelang C, Sassone-Corsi P (2000). "Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA". Mol. Cell. Biol. 20 (13): 4910–21. PMID 10848616.