ROR1

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Tyrosine-protein kinase transmembrane receptor ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is an enzyme that in humans is encoded by the ROR1 gene.[1][2][3] ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family.

Function

The protein encoded by this gene is a receptor tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors.[1] ROR1 is currently under investigation for its role in the metastasis of cancer cells.[4]

ROR1 has recently been shown to be expressed on ovarian cancer stem cell, on which it seems to play a functional role in promoting migration/invasion or spheroid formation in vitro and tumor engraftment in immune-deficient mice. Treatment with a humanized mAb specific for ROR1 (UC-961) could inhibit the capacity of ovarian cancer cells to migrate, form spheroids, or engraft immune-deficient mice. Moreover, such treatment inhibited the growth of tumor xenografts, which in turn had a reduced capacity to engraft immune-deficient mice and were relatively depleted of cells with features of CSC, suggesting that treatment with UC-961 could impair CSC renewal. Collectively, these studies indicate that ovarian CSCs express ROR1, which may be targeted for anti-CSC therapy.[5]

References

  1. 1.0 1.1 "Entrez Gene: receptor tyrosine kinase-like orphan receptor 1".
  2. Masiakowski P, Carroll RD (Dec 1992). "A novel family of cell surface receptors with tyrosine kinase-like domain". The Journal of Biological Chemistry. 267 (36): 26181–90. PMID 1334494.
  3. Reddy UR, Phatak S, Pleasure D (Oct 1996). "Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains". Oncogene. 13 (7): 1555–9. PMID 8875995.
  4. http://www.foxnews.com/health/2013/06/14/stopping-cancer-spread-researchers-identify-protein-that-regulates-cancer/?test=latestnews
  5. Zhang S, Cui B, Lai H, Liu G, Ghia EM, Widhopf GF, Zhang Z, Wu CC, Chen L, Wu R, Schwab R, Carson DA, Kipps TJ (Dec 2014). "Ovarian cancer stem cells express ROR1, which can be targeted for anti-cancer-stem-cell therapy". Proceedings of the National Academy of Sciences of the United States of America. 111 (48): 17266–71. doi:10.1073/pnas.1419599111. PMC 4260559. PMID 25411317.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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