RNF14

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.[1][2][3]

Function

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.[3]

Interactions

RNF14 has been shown to interact with the Androgen receptor.[1][4][5][6]

See also

References

  1. 1.0 1.1 Kang HY, Yeh S, Fujimoto N, Chang C (Apr 1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J Biol Chem. 274 (13): 8570–6. doi:10.1074/jbc.274.13.8570. PMID 10085091.
  2. Ueki N, Seki N, Yano K, Masuho Y, Saito T, Muramatsu M (Jun 1999). "Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif". Biochim Biophys Acta. 1445 (2): 232–6. doi:10.1016/s0167-4781(99)00045-7. PMID 10320776.
  3. 3.0 3.1 "Entrez Gene: RNF14 ring finger protein 14".
  4. Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C (Feb 2002). "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. doi:10.1074/jbc.M108312200. PMID 11673464.
  5. He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
  6. He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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