RHCG

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.[1][2]

Function

RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[3] The structure of the RHCG protein[4] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.

References

  1. "Entrez Gene: RHCG Rh family, C glycoprotein".
  2. Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
  3. Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature. 456 (7220): 339–43. doi:10.1038/nature07518. PMID 19020613.
  4. PDB: 3hd6​; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. doi:10.1073/pnas.1003587107. PMC 2906887. PMID 20457942.

Further reading



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