Prothrombinase

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Prothrombinase is the protein complex which consist of negatively charged phospholipid (phosphatidylserine), prothrombin, Va and Xa.

The prothrombinase complex converts prothrombin, an inactive protease, into thrombin which has proteolytic activity.

Assembly of the prothrombinase complex occurs on activated platelets. In normal conditions platelets do not expose negatively charged phospholipids on the surface. However binding to collagen sets a sequence of biochemical reactions in motion that activate the membrane protein scramblase. Scramblase transports negatively charged phospholipids from the inner leaflet of the membrane to the outer leaflet. The presence of negatively charged phospholipids allows the binding and the formation of the prothrombinase complex.

See also

hemostasis


Cost Effectiveness of Prothrombinase

| group5 = Clinical Trials Involving Prothrombinase | list5 = Ongoing Trials on Prothrombinase at Clinical Trials.govTrial results on ProthrombinaseClinical Trials on Prothrombinase at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Prothrombinase | list6 = US National Guidelines Clearinghouse on ProthrombinaseNICE Guidance on ProthrombinaseNHS PRODIGY GuidanceFDA on ProthrombinaseCDC on Prothrombinase


| group7 = Textbook Information on Prothrombinase | list7 = Books and Textbook Information on Prothrombinase


| group8 = Pharmacology Resources on Prothrombinase | list8 = AND (Dose)}} Dosing of ProthrombinaseAND (drug interactions)}} Drug interactions with ProthrombinaseAND (side effects)}} Side effects of ProthrombinaseAND (Allergy)}} Allergic reactions to ProthrombinaseAND (overdose)}} Overdose information on ProthrombinaseAND (carcinogenicity)}} Carcinogenicity information on ProthrombinaseAND (pregnancy)}} Prothrombinase in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Prothrombinase


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Prothrombinase | list9 = AND (pharmacogenomics)}} Genetics of ProthrombinaseAND (pharmacogenomics)}} Pharmacogenomics of ProthrombinaseAND (proteomics)}} Proteomics of Prothrombinase


| group10 = Newstories on Prothrombinase | list10 = Prothrombinase in the newsBe alerted to news on ProthrombinaseNews trends on Prothrombinase


| group11 = Commentary on Prothrombinase | list11 = Blogs on Prothrombinase

| group12 = Patient Resources on Prothrombinase | list12 = Patient resources on ProthrombinaseDiscussion groups on ProthrombinasePatient Handouts on ProthrombinaseDirections to Hospitals Treating ProthrombinaseRisk calculators and risk factors for Prothrombinase


| group13 = Healthcare Provider Resources on Prothrombinase | list13 = Symptoms of ProthrombinaseCauses & Risk Factors for ProthrombinaseDiagnostic studies for ProthrombinaseTreatment of Prothrombinase

| group14 = Continuing Medical Education (CME) Programs on Prothrombinase | list14 = CME Programs on Prothrombinase

| group15 = International Resources on Prothrombinase | list15 = Prothrombinase en EspanolProthrombinase en Francais

| group16 = Business Resources on Prothrombinase | list16 = Prothrombinase in the MarketplacePatents on Prothrombinase

| group17 = Informatics Resources on Prothrombinase | list17 = List of terms related to Prothrombinase


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