Protein tyrosine phosphatase

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Protein tyrosine phosphatases (PTPs) are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins.


Together with tyrosine kinases, PTPs regulate the phosphorylation state of many important signalling molecules, such as the MAP kinase family.

PTPs are increasingly viewed as integral components of signal transduction cascades, despite little studied and ill-understood compared to Tyrosine Kinases.

PTPs have been implicated in regulation of many cellular processes, including, but not limited to:


See also

External links


  • Alberts, Bruce (2002). Molecular Biology of the Cell Fourth Edition. NYC, NY: Farland Science. ISBN 0-8153-3218-1. Unknown parameter |coauthors= ignored (help) pp 886-887.