Protein Z-related protease inhibitor
Template:Infobox protein Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.
Role in disease
- Water N, Tan T, Ashton F, O'grady A, Day T, Browett P, Ockelford P, Harper P. Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia. Br J Haematol 2004;127:190-4. PubMed.
- Han X, Fiehler R, Broze GJ. Isolation of protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci U S A 1998;95:9250-5. Fulltext. PubMed.
- Han X, Fiehler R, Broze GJ. Characterization of the protein Z-dependent protease inhibitor. Blood 2000;96:3049-55. Fulltext. PubMed.