Protein Z-related protease inhibitor

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Identifiers
Symbol SERPINA10
Entrez 51156
HUGO 15996
OMIM 605271
RefSeq NM_016186
UniProt Q9UK55
Other data
Locus Chr. 14 q32.1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade. It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another circulating protein, to function properly, but this only applies to its inhibition of factor X.

It is about 72 kDa heavy and 444 amino acids large. It is produced by the liver.

Role in disease

Water et al found deficiency of ZPI in 4.4% of a cohort of patients with thrombophilia (a tendency to thrombosis).[1]

History

Han et al first described ZPI in 1998.[2] The same group further characterised it in 2000.[3]

References

  1. Water N, Tan T, Ashton F, O'grady A, Day T, Browett P, Ockelford P, Harper P. Mutations within the protein Z-dependent protease inhibitor gene are associated with venous thromboembolic disease: a new form of thrombophilia. Br J Haematol 2004;127:190-4. PMID 15461625.
  2. Han X, Fiehler R, Broze GJ. Isolation of protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci U S A 1998;95:9250-5. Fulltext. PMID 9689066.
  3. Han X, Fiehler R, Broze GJ. Characterization of the protein Z-dependent protease inhibitor. Blood 2000;96:3049-55. Fulltext. PMID 11049983.
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| group5 = Clinical Trials Involving Protein Z-related protease inhibitor | list5 = Ongoing Trials on Protein Z-related protease inhibitor at Clinical Trials.govTrial results on Protein Z-related protease inhibitorClinical Trials on Protein Z-related protease inhibitor at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Protein Z-related protease inhibitor | list6 = US National Guidelines Clearinghouse on Protein Z-related protease inhibitorNICE Guidance on Protein Z-related protease inhibitorNHS PRODIGY GuidanceFDA on Protein Z-related protease inhibitorCDC on Protein Z-related protease inhibitor


| group7 = Textbook Information on Protein Z-related protease inhibitor | list7 = Books and Textbook Information on Protein Z-related protease inhibitor


| group8 = Pharmacology Resources on Protein Z-related protease inhibitor | list8 = AND (Dose)}} Dosing of Protein Z-related protease inhibitorAND (drug interactions)}} Drug interactions with Protein Z-related protease inhibitorAND (side effects)}} Side effects of Protein Z-related protease inhibitorAND (Allergy)}} Allergic reactions to Protein Z-related protease inhibitorAND (overdose)}} Overdose information on Protein Z-related protease inhibitorAND (carcinogenicity)}} Carcinogenicity information on Protein Z-related protease inhibitorAND (pregnancy)}} Protein Z-related protease inhibitor in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Protein Z-related protease inhibitor


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Protein Z-related protease inhibitor | list9 = AND (pharmacogenomics)}} Genetics of Protein Z-related protease inhibitorAND (pharmacogenomics)}} Pharmacogenomics of Protein Z-related protease inhibitorAND (proteomics)}} Proteomics of Protein Z-related protease inhibitor


| group10 = Newstories on Protein Z-related protease inhibitor | list10 = Protein Z-related protease inhibitor in the newsBe alerted to news on Protein Z-related protease inhibitorNews trends on Protein Z-related protease inhibitor</small>


| group11 = Commentary on Protein Z-related protease inhibitor | list11 = Blogs on Protein Z-related protease inhibitor

| group12 = Patient Resources on Protein Z-related protease inhibitor | list12 = Patient resources on Protein Z-related protease inhibitorDiscussion groups on Protein Z-related protease inhibitorPatient Handouts on Protein Z-related protease inhibitorDirections to Hospitals Treating Protein Z-related protease inhibitorRisk calculators and risk factors for Protein Z-related protease inhibitor


| group13 = Healthcare Provider Resources on Protein Z-related protease inhibitor | list13 = Symptoms of Protein Z-related protease inhibitorCauses & Risk Factors for Protein Z-related protease inhibitorDiagnostic studies for Protein Z-related protease inhibitorTreatment of Protein Z-related protease inhibitor

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| group16 = Business Resources on Protein Z-related protease inhibitor | list16 = Protein Z-related protease inhibitor in the MarketplacePatents on Protein Z-related protease inhibitor

| group17 = Informatics Resources on Protein Z-related protease inhibitor | list17 = List of terms related to Protein Z-related protease inhibitor


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