Prostanoid

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Prostanoid is the term used to describe a subclass of eicosanoids consisting of: the prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction) and the prostacyclins (active in the resolution phase of inflammation.)

See also main articles at Prostaglandin, Prostacyclin and Thromboxane

Biosynthesis

File:Prostanoid synthesis.svg Cyclooxygenase (COX) catalyzes the conversion of the free essential fatty acids to prostanoids by a two-step process. In the first step, two molecules of O2 are added as two peroxide linkages and a 5-member carbon ring is forged near the middle of the fatty acid chain. This forms the short-lived, unstable intermediate Prostaglandin G (PGG). One of the peroxide linkages sheds a single oxygen, forming PGH. (See diagrams and more detail at Cyclooxygenase). All other prostanoids originate from PGH, (as PGH1, PGH2, or PGH3).

Figure 1 shows how PGH2 (derived from Arachidonic acid) is converted:

The three classes of prostanoids have distinctive rings in the center of the molecule. They differ in their structures. The PGH compounds (parents to all the rest) have a 5-carbon ring, bridged by two oxygens (a peroxide.) The derived prostaglandins contain a single, unsaturated 5-carbon ring. In prostacyclins, this ring is conjoined to another oxygen-containing ring. In thromboxanes the ring becomes a 6-member ring with one oxygen.

Production of PGE2 in bacterial and viral infections appears to be stimulated by certain cytokines, e.g., interleukin-1.[1]

See also

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| group5 = Clinical Trials Involving Prostanoid | list5 = Ongoing Trials on Prostanoid at Clinical Trials.govTrial results on ProstanoidClinical Trials on Prostanoid at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Prostanoid | list6 = US National Guidelines Clearinghouse on ProstanoidNICE Guidance on ProstanoidNHS PRODIGY GuidanceFDA on ProstanoidCDC on Prostanoid


| group7 = Textbook Information on Prostanoid | list7 = Books and Textbook Information on Prostanoid


| group8 = Pharmacology Resources on Prostanoid | list8 = AND (Dose)}} Dosing of ProstanoidAND (drug interactions)}} Drug interactions with ProstanoidAND (side effects)}} Side effects of ProstanoidAND (Allergy)}} Allergic reactions to ProstanoidAND (overdose)}} Overdose information on ProstanoidAND (carcinogenicity)}} Carcinogenicity information on ProstanoidAND (pregnancy)}} Prostanoid in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Prostanoid


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Prostanoid | list9 = AND (pharmacogenomics)}} Genetics of ProstanoidAND (pharmacogenomics)}} Pharmacogenomics of ProstanoidAND (proteomics)}} Proteomics of Prostanoid


| group10 = Newstories on Prostanoid | list10 = Prostanoid in the newsBe alerted to news on ProstanoidNews trends on Prostanoid


| group11 = Commentary on Prostanoid | list11 = Blogs on Prostanoid

| group12 = Patient Resources on Prostanoid | list12 = Patient resources on ProstanoidDiscussion groups on ProstanoidPatient Handouts on ProstanoidDirections to Hospitals Treating ProstanoidRisk calculators and risk factors for Prostanoid


| group13 = Healthcare Provider Resources on Prostanoid | list13 = Symptoms of ProstanoidCauses & Risk Factors for ProstanoidDiagnostic studies for ProstanoidTreatment of Prostanoid

| group14 = Continuing Medical Education (CME) Programs on Prostanoid | list14 = CME Programs on Prostanoid

| group15 = International Resources on Prostanoid | list15 = Prostanoid en EspanolProstanoid en Francais

| group16 = Business Resources on Prostanoid | list16 = Prostanoid in the MarketplacePatents on Prostanoid

| group17 = Informatics Resources on Prostanoid | list17 = List of terms related to Prostanoid


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