Prephenate dehydratase

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In enzymology, a prephenate dehydratase (EC 4.2.1.51) is an enzyme that catalyzes the chemical reaction

prephenate phenylpyruvate + H2O + CO2

Hence, this enzyme has one substrate, prephenate, but 3 products: phenylpyruvate, H2O, and CO2.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming). This enzyme is also called prephenate hydro-lyase (decarboxylating). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QMX.

References

  • IUBMB entry for 4.2.1.51
  • BRENDA references for 4.2.1.51 (Recommended.)
  • PubMed references for 4.2.1.51
  • PubMed Central references for 4.2.1.51
  • Google Scholar references for 4.2.1.51
  • CERUTTI P, GUROFF G (1965). "ENZYMATIC FORMATION OF PHENYLPYRUVIC ACID IN PSEUDOMONAS SP. (ATCC 11299A) AND ITS REGULATION". J. Biol. Chem. 240: 3034&ndash, 8. PMID 14342329.
  • COTTON RG, GIBSON F (1965). "THE BIOSYNTHESIS OF PHENYLALANINE AND TYROSINE; ENZYMES CONVERTING CHORISMIC ACID INTO PREPHENIC ACID AND THEIR RELATIONSHIPS TO PREPHENATE DEHYDRATASE AND PREPHENATE DEHYDROGENASE". Biochim. Biophys. Acta. 100: 76&ndash, 88. PMID 14323651.
  • Schmidt JC and Zalkin H (1969). "Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium". Biochemistry. 8: 174&ndash, 181.

External links

The CAS registry number for this enzyme class is 9044-88-6.

Gene Ontology (GO) codes

Template:4.2-enzyme-stub


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