Prenylamine

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Prenylamine
Prenylamine.png
Clinical data
ATC code
Identifiers
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC24H27N
Molar mass329.48 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which is used as a vasodilator in the treatment of angina pectoris. It has been shown to partially metabolize to amphetamine and can cause false positives for it in drug tests.[1][2][3] Prenylamine also appears to act as a vesicular monoamine transporter inhibitor, and has been demonstrated to deplete vesicular monoamine neurotransmitter stores similarly to reserpine.[4]

References

  1. Kraemer T, Roditis SK, Peters FT, Maurer HH (March 2003). "Amphetamine concentrations in human urine following single-dose administration of the calcium antagonist prenylamine-studies using fluorescence polarization immunoassay (FPIA) and GC-MS". Journal of Analytical Toxicology. 27 (2): 68–73. doi:10.1093/jat/27.2.68. PMID 12669999.
  2. Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metabolism Reviews. 32 (1): 15–44. doi:10.1081/DMR-100100562. PMID 10711406.
  3. Cody JT (May 2002). "Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results". Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine. 44 (5): 435–50. doi:10.1097/00043764-200205000-00012. PMID 12024689.
  4. Bagchi SP (1990). "Antidopaminergic action of verapamil and several other drugs: inactivation of vesicular dopamine". Life Sciences. 46 (12): 857–63. doi:10.1016/0024-3205(90)90115-8. PMID 1969603.

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