Pott's disease pathophysiology

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Pott's disease Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hardik Patel, M.D.; Aravind Kuchkuntla, M.B.B.S[2]

Overview

Pott's disease occurs usually due to hematogenous spread of tuberculous infection from an extraspinal source. Pott's disease usually involves more than one vertebra and manifests as a combination of osteomyelitis and arthritis.

Pathophysiology

Source of infection

Mode of Spread

Pathogenesis

Genetics

Microscopic Pathology

References

  1. Rajasekaran S, Kanna RM, Shetty AP (2014). "Pathophysiology and Treatment of Spinal Tuberculosis". JBJS Rev. 2 (9). doi:10.2106/JBJS.RVW.M.00130. PMID 27490153.
  2. Cooper C, Fellner R, Heubi O, Maixner F, Zink A, Lösch S (2016). "Tuberculosis in early medieval Switzerland--osteological and molecular evidence". Swiss Med Wkly. 146: w14269. doi:10.4414/smw.2016.14269. PMID 26826871.
  3. Batirel A, Erdem H, Sengoz G, Pehlivanoglu F, Ramosaco E, Gülsün S; et al. (2015). "The course of spinal tuberculosis (Pott disease): results of the multinational, multicentre Backbone-2 study". Clin Microbiol Infect. 21 (11): 1008.e9–1008.e18. doi:10.1016/j.cmi.2015.07.013. PMID 26232534.
  4. Formica M, Cavagnaro L, Formica C (2015). "Pott disease". Spine J. 15 (3): 556–7. doi:10.1016/j.spinee.2014.11.006. PMID 25459741.
  5. Kim JH, Kim SH, Choi JI, Lim DJ (2014). "Atypical noncontiguous multiple spinal tuberculosis: a case report". Korean J Spine. 11 (2): 77–80. doi:10.14245/kjs.2014.11.2.77. PMC 4124923. PMID 25110488.
  6. 6.0 6.1 6.2 Ekinci S, Tatar O, Akpancar S, Bilgic S, Ersen O (2015). "Spinal Tuberculosis". J Exp Neurosci. 9: 89–90. doi:10.4137/JEN.S32842. PMC 4644140. PMID 26609247.
  7. 7.0 7.1 Kilborn T, Janse van Rensburg P, Candy S (2015). "Pediatric and adult spinal tuberculosis: imaging and pathophysiology". Neuroimaging Clin N Am. 25 (2): 209–31. doi:10.1016/j.nic.2015.01.002. PMID 25952174.
  8. Tin SS, Wiwanitkit V (2014). "Noncontiguous multiple spinal tuberculosis". Korean J Spine. 11 (4): 259. doi:10.14245/kjs.2014.11.4.259. PMC 4303286. PMID 25620992.
  9. Shim HK, Cho HL, Lee SH (2014). "Spinal tuberculosis at the posterior element of spinal column: case report". Clin Neurol Neurosurg. 124: 146–50. doi:10.1016/j.clineuro.2014.05.021. PMID 25051165.
  10. Zhang HQ, Deng A, Guo CF, Wang YX, Chen LQ, Wang YF; et al. (2010). "Association between FokI polymorphism in vitamin D receptor gene and susceptibility to spinal tuberculosis in Chinese Han population". Arch Med Res. 41 (1): 46–9. doi:10.1016/j.arcmed.2009.12.004. PMID 20430254.
  11. Panwar A, Garg RK, Malhotra HS, Jain A, Singh AK, Prakash S; et al. (2016). "25-Hydroxy Vitamin D, Vitamin D Receptor and Toll-like Receptor 2 Polymorphisms in Spinal Tuberculosis: A Case-Control Study". Medicine (Baltimore). 95 (17): e3418. doi:10.1097/MD.0000000000003418. PMC 4998689. PMID 27124026.



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