Polyphosphate kinase

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In enzymology, a polyphosphate kinase (EC 2.7.4.1) is an enzyme that catalyzes the chemical reaction

ATP + (phosphate)n ADP + (phosphate)n+1

Thus, the two substrates of this enzyme are ATP and (phosphate)n, whereas its two products are ADP and (phosphate)n+1.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:polyphosphate phosphotransferase. This enzyme is also called polyphosphoric acid kinase. This enzyme participates in oxidative phosphorylation.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1XDO, 1XDP, and 2O8R.

References

  • IUBMB entry for 2.7.4.1
  • BRENDA references for 2.7.4.1 (Recommended.)
  • PubMed references for 2.7.4.1
  • PubMed Central references for 2.7.4.1
  • Google Scholar references for 2.7.4.1
  • HOFFMANN-OSTENHOF O, KENEDY J, KECK K, GABRIEL O, SCHONFELLINGER HW (1954). "[A new transphosphorylase from yeast.]". Biochim. Biophys. Acta. 14: 285. PMID 13172250.
  • KORNBERG A, KORNBERG SR, SIMMS ES (1956). "Metaphosphate synthesis by an enzyme from Escherichia coli". Biochim. Biophys. Acta. 20: 215&ndash, 27. PMID 13315368.
  • Muhammed A (1961). "Studies on biosynthesis of polymetaphosphate by an enzyme from Corynebacterium xerosis". Biochim. Biophys. Acta. 54: 121&ndash, 132.

External links

The CAS registry number for this enzyme class is 9026-44-2.

Gene Ontology (GO) codes


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