Polyketide

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Polyketides are secondary metabolites from bacteria, fungi, plants, and animals. Secondary metabolites seem to be unnecessary for an organism’s ontogeny, but appear to have applications such as defence and intercellular communication. Polyketides are derived from the polymerization of acetyl and propionyl subunits in a similar process to fatty acid synthesis. They also serve as building blocks for a broad range of natural products or are derivatized.

Polyketides are structurally a very diverse family of natural products with an extremely broad range of biological activities and pharmacological properties. Polyketide antibiotics, antifungals, cytostatics, anticholesterolemics, antiparasitics, coccidiostatics, animal growth promotants and natural insecticides are in commercial use.

Examples

Biosynthesis

Polyketides are synthesized by one or more specialized polyketide synthase (PKS) enzymes.

See also

Cost Effectiveness of Polyketide

| group5 = Clinical Trials Involving Polyketide | list5 = Ongoing Trials on Polyketide at Clinical Trials.govTrial results on PolyketideClinical Trials on Polyketide at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Polyketide | list6 = US National Guidelines Clearinghouse on PolyketideNICE Guidance on PolyketideNHS PRODIGY GuidanceFDA on PolyketideCDC on Polyketide


| group7 = Textbook Information on Polyketide | list7 = Books and Textbook Information on Polyketide


| group8 = Pharmacology Resources on Polyketide | list8 = AND (Dose)}} Dosing of PolyketideAND (drug interactions)}} Drug interactions with PolyketideAND (side effects)}} Side effects of PolyketideAND (Allergy)}} Allergic reactions to PolyketideAND (overdose)}} Overdose information on PolyketideAND (carcinogenicity)}} Carcinogenicity information on PolyketideAND (pregnancy)}} Polyketide in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Polyketide


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Polyketide | list9 = AND (pharmacogenomics)}} Genetics of PolyketideAND (pharmacogenomics)}} Pharmacogenomics of PolyketideAND (proteomics)}} Proteomics of Polyketide


| group10 = Newstories on Polyketide | list10 = Polyketide in the newsBe alerted to news on PolyketideNews trends on Polyketide


| group11 = Commentary on Polyketide | list11 = Blogs on Polyketide

| group12 = Patient Resources on Polyketide | list12 = Patient resources on PolyketideDiscussion groups on PolyketidePatient Handouts on PolyketideDirections to Hospitals Treating PolyketideRisk calculators and risk factors for Polyketide


| group13 = Healthcare Provider Resources on Polyketide | list13 = Symptoms of PolyketideCauses & Risk Factors for PolyketideDiagnostic studies for PolyketideTreatment of Polyketide

| group14 = Continuing Medical Education (CME) Programs on Polyketide | list14 = CME Programs on Polyketide

| group15 = International Resources on Polyketide | list15 = Polyketide en EspanolPolyketide en Francais

| group16 = Business Resources on Polyketide | list16 = Polyketide in the MarketplacePatents on Polyketide

| group17 = Informatics Resources on Polyketide | list17 = List of terms related to Polyketide


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