Pirenzepine

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Pirenzepine
Systematic (IUPAC) name
11-[(4-Methylpiperazin-1yl)acetyl]6,11-dihydro-5H-pyrido[2,3-b][1,4]benzodiazepin-6-on
Identifiers
CAS number 28797-61-7
ATC code A02BX03
PubChem 4848
DrugBank APRD00515
Chemical data
Formula C19H21N5O2 
Mol. mass 351.403 g/mol
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes ?

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pirenzepine (marketed by Merck Marker under the trade-name Gastrozepin) is used in the treatment of peptic ulcers, as it reduces gastric acid secretion and reduces muscle spasm. It is in a class of drugs known as Muscarinic receptor antagonists - acetylcholine being the neurotransmitter of the parasympathetic nervous system which initiates the rest-and-digest state (as opposed to fight-or-flight), the result being an increase in gastric motility and digestion. It has no effects on the brain and spinal cord as it cannot diffuse through the blood-brain barrier.

Pirenzepine has been investigated for use in myopia control.[1]

References

  1. Czepita D (2005). "Fundamentals of modern treatment of myopia". Ann Acad Med Stetin. 51 (2): 5–9. PMID 16519089. 



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