Phthalylsulfathiazole

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Phthalylsulfathiazole
Systematic (IUPAC) name
2-[ [4-(1,3-thiazol-2-ylsulfamoyl)phenyl]carbamoyl]benzoic acid
Identifiers
CAS number ?
ATC code A07AB02
PubChem 4806
Chemical data
Formula C17H13N3O5S2 
Mol. mass 403.43222 g/mol
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes ?


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Phthalylsulfathiazole belongs to the group of drugs called sulfonamides. The drug is a broad spectrum antimicrobial that can treat different types of infections including intestinal. The mechanism of action depends is based on competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase activity, that in turn leads to impaired synthesis of dihydrofolic acid and as a result its active metabolite that is necessary for the synthesis of purine and pyrimidine.

The drug is indicated in treatment of dysentery, colitis, gastroenteritis and intestinal surgery. Adverse effects may include allergic reactions, vitamin B insufficiency, agranulocytosis and aplastic anemia.

References




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