Phosphogluconate dehydratase

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In enzymology, a phosphogluconate dehydratase (EC 4.2.1.12) is an enzyme that catalyzes the chemical reaction

6-phospho-D-gluconate 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

Hence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-D-gluconate hydro-lyase. This enzyme participates in pentose phosphate pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.

References

  • IUBMB entry for 4.2.1.12
  • BRENDA references for 4.2.1.12 (Recommended.)
  • PubMed references for 4.2.1.12
  • PubMed Central references for 4.2.1.12
  • Google Scholar references for 4.2.1.12
  • MELOCHE HP, WOOD WA (1964). "THE MECHANISM OF 6-PHOSPHOGLUCONIC DEHYDRASE". J. Biol. Chem. 239: 3505&ndash, 10. PMID 14245409.

External links

The CAS registry number for this enzyme class is 9024-33-3.

Gene Ontology (GO) codes

Template:4.2-enzyme-stub


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