Phosphatidylinositol diacylglycerol-lyase

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Phosphatidylinositol-specific phospholipase C, image from OPM database

In enzymology, a phosphatidylinositol diacylglycerol-lyase (EC is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

Hence, this enzyme has one substrate, 1-phosphatidyl-1D-myo-inositol, and two products, 1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). This enzyme participates in inositol phosphate metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T6M and 2OR2.


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  • Allan D, Michell RH (1974). "Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0". Biochem. J. 142: 591&ndash, 7. PMID 4377210.
  • Friedel RO, Brown JD, Durell (1967). "Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain". Biochim. Biophys. Acta. 144: 684&ndash, 6. PMID 4294905.
  • Irvine RF (1982). "The enzymology of stimulated inositol lipid turnover". Cell. Calcium. 3: 295&ndash, 309. PMID 6297738.
  • Michell RH, Allan D (1975). "Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus)". FEBS. Lett. 53: 302&ndash, 4. PMID 236918.
  • Low MG, Finean JB (1977). "Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C". Biochem. J. 167: 281&ndash, 4. PMID 588258.
  • Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG (1988). "Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C". Nucleic. Acids. Res. 16: 10383. PMID 3194218.

External links

The CAS registry number for this enzyme class is 37288-19-0.

Gene Ontology (GO) codes