Phenylpyruvate tautomerase

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In enzymology, a phenylpyruvate tautomerase (EC 5.3.2.1) is an enzyme that catalyzes the chemical reaction

keto-phenylpyruvate enol-phenylpyruvate

Hence, this enzyme has one substrate, keto-phenylpyruvate, and one product, enol-phenylpyruvate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting keto- and enol-groups. The systematic name of this enzyme class is phenylpyruvate keto---enol-isomerase. This enzyme is also called phenylpyruvic keto-enol isomerase. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GYJ, 1GYX, 1GYY, 2GDG, 2OOH, 2OOW, and 2OOZ.

References

  • IUBMB entry for 5.3.2.1
  • BRENDA references for 5.3.2.1 (Recommended.)
  • PubMed references for 5.3.2.1
  • PubMed Central references for 5.3.2.1
  • Google Scholar references for 5.3.2.1
  • Blasi F, Fragomele F, Covelli I (1969). "Thyroidal phenylpyruvate tautomerase. Isolation and characterization". J. Biol. Chem. 244: 4864&ndash, 70. PMID 5824560.
  • Knox WE (1955). "p-Hydroxyphenylpyruvate enol-keto tautomerase". Methods Enzymol. 2: 289&ndash, 295.
  • KNOX WE, PITT BM (1957). "Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids". J. Biol. Chem. 225: 675&ndash, 88. PMID 13416270.

External links

The CAS registry number for this enzyme class is 9023-54-5.

Gene Ontology (GO) codes


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