Petromyzonol sulfotransferase

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In enzymology, a petromyzonol sulfotransferase (EC 2.8.2.31) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol adenosine 3',5'-bisphosphate + 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and 5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol, whereas its two products are adenosine 3',5'-bisphosphate and 5alpha-cholan-3alpha,7alpha,12alpha-triol 24-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-te trol sulfotransferase. This enzyme is also called PZ-SULT.

References

  • IUBMB entry for 2.8.2.31
  • BRENDA references for 2.8.2.31 (Recommended.)
  • PubMed references for 2.8.2.31
  • PubMed Central references for 2.8.2.31
  • Google Scholar references for 2.8.2.31
  • Venkatachalam KV, Llanos DE, Karami KJ, Malinovskii VA (2004). "Isolation, partial purification, and characterization of a novel petromyzonol sulfotransferase from Petromyzon marinus (lamprey) larval liver". J. Lipid. Res. 45: 486&ndash, 95. PMID 14657197.

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