Peripheral giant cell granuloma

Jump to: navigation, search


Overview

Peripheral giant cell granuloma
ICD-10 K06.8
ICD-9 523.8
DiseasesDB 30735
MeSH D006101

WikiDoc Resources for Peripheral giant cell granuloma

Articles

Most recent articles on Peripheral giant cell granuloma

Most cited articles on Peripheral giant cell granuloma

Review articles on Peripheral giant cell granuloma

Articles on Peripheral giant cell granuloma in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Peripheral giant cell granuloma

Images of Peripheral giant cell granuloma

Photos of Peripheral giant cell granuloma

Podcasts & MP3s on Peripheral giant cell granuloma

Videos on Peripheral giant cell granuloma

Evidence Based Medicine

Cochrane Collaboration on Peripheral giant cell granuloma

Bandolier on Peripheral giant cell granuloma

TRIP on Peripheral giant cell granuloma

Clinical Trials

Ongoing Trials on Peripheral giant cell granuloma at Clinical Trials.gov

Trial results on Peripheral giant cell granuloma

Clinical Trials on Peripheral giant cell granuloma at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Peripheral giant cell granuloma

NICE Guidance on Peripheral giant cell granuloma

NHS PRODIGY Guidance

FDA on Peripheral giant cell granuloma

CDC on Peripheral giant cell granuloma

Books

Books on Peripheral giant cell granuloma

News

Peripheral giant cell granuloma in the news

Be alerted to news on Peripheral giant cell granuloma

News trends on Peripheral giant cell granuloma

Commentary

Blogs on Peripheral giant cell granuloma

Definitions

Definitions of Peripheral giant cell granuloma

Patient Resources / Community

Patient resources on Peripheral giant cell granuloma

Discussion groups on Peripheral giant cell granuloma

Patient Handouts on Peripheral giant cell granuloma

Directions to Hospitals Treating Peripheral giant cell granuloma

Risk calculators and risk factors for Peripheral giant cell granuloma

Healthcare Provider Resources

Symptoms of Peripheral giant cell granuloma

Causes & Risk Factors for Peripheral giant cell granuloma

Diagnostic studies for Peripheral giant cell granuloma

Treatment of Peripheral giant cell granuloma

Continuing Medical Education (CME)

CME Programs on Peripheral giant cell granuloma

International

Peripheral giant cell granuloma en Espanol

Peripheral giant cell granuloma en Francais

Business

Peripheral giant cell granuloma in the Marketplace

Patents on Peripheral giant cell granuloma

Experimental / Informatics

List of terms related to Peripheral giant cell granuloma

Peripheral giant cell granuloma (PGCG) is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, though not because they occur together. Instead, the three are associated with each other because they appear frequently on gingiva and they also begin with the letter "p": pyogenic granuloma and peripheral ossifying fibroma. Because of its similar microscopic appearance to the bony lesions called central giant cell granulomas, peripheral giant cell granulomas are considered by some researchers to be a soft tissue equivalent.

The appearance of peripheral giant cell granulomas is similar to pyogenic granulomas. The color ranges from red to bluish-purple, but is usually more blue in comparison to pyogenic granulomas. It can be sessile or pedunculated with the size usually being less than 2 cm.

There is a gender difference with 60% of the disease occurring in females. The prevalence of peripheral giant cell granulomas is highest around 50 - 60 years of age. It appears only on the gingiva or on an edentulous (without teeth) alveolar ridge. It is more often found in the mandible rather than the maxilla but can be found in either anterior or posterior areas. The underlying alveolar bone can be destroyed, leaving a unique appearance referred to as "cupping resorption" or "saucerization".

Histology

Peripheral giant cell granulomas appear microscopically as a large number of multinucleated giant cells, which can have up to dozens of nuclei. Additionally, there are mesenchymal cells that are ovoid and spindle-shaped. Near the borders of the lesion, deposits of hemosiderin and hemorrhage is often found. In 50% of cases, ulcerations are present.

Treatment

Treatment usually involves surgical removal of the lesion down to the bone. If there are any adjacent teeth, they are cleaned thoroughly to remove any possible source of irritation. Recurrence is around 10%.

References

  • Kahn, Michael A. Basic Oral and Maxillofacial Pathology. Volume 1. 2001.



Linked-in.jpg