Peptide transporter 1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene.[1][2] PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.[3]

Function

SLC15A1is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.[1][3]

See also

References

  1. 1.0 1.1 "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1".
  2. Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH (March 1995). "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization". J. Biol. Chem. 270 (12): 6456–63. doi:10.1074/jbc.270.12.6456. PMID 7896779.
  3. 3.0 3.1 Adibi SA (July 1997). "The oligopeptide transporter (Pept-1) in human intestine: biology and function". Gastroenterology. 113 (1): 332–40. doi:10.1016/S0016-5085(97)70112-4. PMID 9207295.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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