Parathyroid hormone receptor

Jump to: navigation, search
parathyroid hormone 1 receptor
Identifiers
SymbolPTH1R
Alt. symbolsPTHR, PFE
Entrez5745
HUGO9608
OMIM168468
RefSeqNM_000316
UniProtQ03431
Other data
LocusChr. 3 p22-p21.1
parathyroid hormone 2 receptor
Identifiers
SymbolPTH2R
Entrez5746
HUGO9609
OMIM601469
RefSeqNM_005048
UniProtP49190
Other data
LocusChr. 2 q33

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]

References

  1. Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. doi:10.1097/00041552-199407000-00002. PMID 8076140.
  2. Mannstadt M, Jüppner H, Gardella TJ (1999). "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. PMID 10564229.
  3. Offermanns S, Iida-Klein A, Segre GV, Simon MI (1996). "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. doi:10.1210/me.10.5.566. PMID 8732687.
  4. Usdin TB, Bonner TI, Hoare SR (2002). "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels. 8 (3–4): 211–8. doi:10.1080/10606820213682. PMID 12529938.

External links


Linked-in.jpg