PURB

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Identifiers
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External IDsGeneCards: [1]
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SpeciesHumanMouse
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Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.[1][2]

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.[2]

References

  1. Bergemann AD, Ma ZW, Johnson EM (Dec 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Mol Cell Biol. 12 (12): 5673–82. doi:10.1128/mcb.12.12.5673. PMC 360507. PMID 1448097.
  2. 2.0 2.1 "Entrez Gene: PURB purine-rich element binding protein B".

Further reading




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