The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.
Wagner J, Gordon LA, Heng HH, Tremblay ML, Olsen AS (1997). "Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3". Genomics. 38 (1): 76–8. doi:10.1006/geno.1996.0594. PMID8954782.
Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID9624153.
Blanchetot C, den Hertog J (2000). "Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs". J. Biol. Chem. 275 (17): 12446–52. doi:10.1074/jbc.275.17.12446. PMID10777529.
Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J (2003). "Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases". J. Biol. Chem. 277 (49): 47263–9. doi:10.1074/jbc.M205810200. PMID12376545.
Sato M, Takahashi K, Nagayama K, Arai Y, Ito N, Okada M, Minna JD, Yokota J, Kohno T (2005). "Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer". Genes Chromosomes Cancer. 44 (4): 405–14. doi:10.1002/gcc.20253. PMID16114034.