Coronary artery calcification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The coronary angiogram is fairly insensitive to the presence of lesion calcification, particularly the presence of deep vessel wall calcification. Intravascular ultrasound is much more sensitive in the assessment of vessel wall calcification. Conventional coronary angiography has limited sensitivity for the detection of smaller amounts of calcium, and has moderate sensitivity for the detection of extensive lesion calcium (sensitivity 60% and 85% for three- and four-quadrant calcium, respectively).[1] Calcification is often associated with older saphenous vein graft age, insulin–dependent diabetics, and smoking.[2] Calcified lesions pose several challenges to the interventional cardiologists as they are sometimes difficult to cross with the angioplasty equipment, they are less likely to fully dilate, they are prone to recoil, and they often do not allow for full expansion of the stent. Failure to fully expand the stent may result in restenosis. Stents should be deployed only after ensuring that the lesion can be fully expanded by a conventional balloon angioplasty.

Grading System

  • None: no radiopacity.
  • Mild: faint radiopacities noted during the cardiac cycles.
  • Moderate: dense radioapcities noted only during the cardiac cycle.
  • Severe: dense radiopacities noted without cardiac motion before contrast injection generally compromising both sides of the arterial lumen.

Diagnosis

The coronary angiogram is fairly insensitive to the presence of lesion calcification, particularly the presence of deep vessel wall calcification. Intravascular ultrasound is much more sensitive in the assessment of vessel wall calcification. Conventional coronary angiography has limited sensitivity for the detection of smaller amounts of calcium, and has moderate sensitivity for the detection of extensive lesion calcium (sensitivity 60% and 85% for three- and four-quadrant calcium, respectively). [1] Calcification of SVGs is generally within the reference vessel wall rather than within the lesion itself. Calcification is often associated with older graft age, insulin–dependent diabetics, and smoking. [2]

Treatment

Calcified lesions pose several challenges to the interventional cardiologists as they are sometimes difficult to cross with the angioplasty equipment, they are less likely to fully dilate, they are prone to recoil, and they often do not allow for full expansion of the stent. Failure to fully expand the stent may result in restenosis. Rotational atherectomy is frequently employed following unsuccessful pre-dilating PTCA to perform plaque modification. Stents should be deployed only after ensuring that the lesion can be fully expanded by a conventional balloon angioplasty.

PCI Complications and Technical Challenges

Reduced Compliance of the Vessel

The presence of coronary calcification reduces the compliance of the vessel, and it may predispose calcified plaque–normal wall interfaces to dissections after balloon angioplasty.

Reduced Ability to Cross the Lesion

Reduced Ability to Fully Dilate the Lesion

PCI Techniques

Guidewire Technique

Often times hydrophilic guidewires with a core that extends to the tip are necessary to cross heavily calcified lesions. Once the lesion is crossed, then a more flexible and less traumatic wire can be inserted distally to minimize vessel, and to minimize the potential for vessel perforation. If there is the difficulty in delivering the equipment, then a more rigid wire such as a stabilizer wire can be used to facilitate passage of devices. Sometimes two wires are used in the "buddy wire technique" to straighten the vessel and facilitate delivery of devices.

Balloon Dilation

Calcified plaques usually require higher balloon pressures to fully expand than normal plaques. Because of this, non-compliant balloons may be a better choice than compliant or semi-compliant balloons. Differential expansion of compliant or semi-compliant balloons inside a particular lesion may jeopardize less diseased segments if the balloon expands greater than the vessel's native diameter. On the contrary, non-compliant balloons allow for a more uniform expansion at high pressures and therefore may be a better choice to apply focused pressure at the calcified plaque. Another option is to place a second "buddy" wire adjacent to the balloon to improve the ability to dilate calcified plaque.

If pre-dilatation fails to fully expand a calcified stenosis, then the risks and benefits of stent deployment should be carefully considered due to the risk of incomplete expansion and future restenosis.

Intravascular Ultrasound (IVUS)

IVUS is a medical imaging methodology that uses a specially designed catheter with a miniaturized ultrasound probe attached to the distal end of the catheter. The proximal end of the catheter is attached to computerized ultrasound equipment. It allows the application of ultrasound technology to see from inside blood vessels out through the surrounding blood column, visualizing the endothelium (inner wall) of blood vessels in living individuals. IVUS is used in the coronary arteries to determine the amount of atheromatous plaque built up at any particular point in the epicardial coronary artery.

While coronary angiography by fluroscopy is limited in its detection and severity assessment of coronary calcification, IVUS can assess the extent of calcification and may be particularly useful for instances when the reason for poor balloon expansion is uncertain. Although this approach has its advantages over angiography, heavy involvement of superficial, sub-endothelial calcification may require rotational atherectomy.

Cutting Balloon and FX MiniRailTM

A cutting balloon is an angioplasty device used in percutaneous coronary interventions. It has a special balloon tip with small blades, that are activated when the balloon is inflated. This procedure is different from rotational atherectomy, in which a diamond tipped device spins at high revolutions to cut away calcific (chalky) atheroma usually prior to coronary stenting.

This technique can be useful in treating calcified lesions because the microsurgical blades on the surface of the balloon may help to score and modify calcified plaques. Generally, if a cutting balloon will cross the lesion, a stent can be delivered. Although this technique has its advantages, there are certain additional considerations that must be made before deciding to use this procedure. For one, despite their usefulness, these balloons are often more difficult to deliver past tortuous or calcified segments, so extra care must be used. Also, there were no significant differences observed in rates of restenosis when using this procedure.

Rotational Atherectomy

Rotational atherectomy is an invasive method of removing plaque and blockages from an artery and subsequently widening arteries that have been narrowed by arterial disease. Unlike angioplasty and stents of blocked arteries that simply push blockages aside into the wall of the artery, rotational atherectomy involves inserting a thin catheter with a rotating blade on its end into the artery. The rotating edge is used to remove plaque buildups, thereby opening the artery and restoring normal blood flow.

Rotational atherectomy is frequently employed following unsuccessful pre-dilating PTCA to perform plaque modification. This procedure facilitates PTCA by creating micro-fractures, removing calcified plaque, and increasing vessel compliance. Despite its usefulness in treating calcified lesions, certain precautions should be taken. In an effort to limit the risk of vessel laceration, smaller diameter burrs are now preferred. A general guideline to use is that the initial burr to luminal ratio should be 1:2. Additional caution should be taken when a coronary dissection is present, as rotational atherectomy may propagate the dissection.

  • Rotational atherectomy in severe lesion calcification: Rotational atherectomy is the preferred pretreatment method in patients with severe lesion calcification, particularly ostial lesions, and facilitates the delivery and expansion of coronary stents by creating microdissection planes within the fibrocalcific plaque. Yet even with these contemporary methods, the presence of moderate or severe coronary calcification is associated with reduced procedural success and higher complication rates[4], including stent dislodgement.
  • Rotational atherectomy in mild-moderate calcifications: In less severely calcified lesions, no differences in restenosis rates were found after paclitaxel-eluting stent implantation in calcified and non-calcified vessels. [5]

Caution should be used in the patient with a low ejection fraction as distal embolization from rotational atherectomy can result in a decline and LV function. Also, tortuous segments with acute bends should not be treated with rotational atherectomy is there is an increased risk of vessel dissection at the site of acute bends and turns.

Directional Coronary Atherectomy (DCA)

DCA involves inserting a thin, flexible catheter with a small blade on its end into the artery, which cuts off plaque buildups. These plaque shavings are caught with the catheter and are subsequently removed from the artery.[6]

One problem that may arise during the procedure is that heavy calcification proximal to the target lesion may limit deliverability of the device and its success.

Excimer Laser Coronary Atherectomy/Angioplasty (ECLA)

ECLA uses a laser, instead of a traditional blade, to perform atherectomy and angioplasty. The excimer laser is a pulsed ultraviolet laser that can erode calcified plaque while also causing minimal thermal tissue injury.[7]

One advantage of using ELCA is that it fractures calcified plaques, thereby facilitating PTCA. However, it also has a higher equipment cost and has a lesser ease of use than rotational atherectomy. Furthermore, it is more commonly used in lower extremity peripheral arterial disease than in coronary artery disease (CAD).

Stents

In cardiology, a stent is a tube that is inserted into an artery to counteract significant decreases in vessel diameter by acutely propping it open.

In the treatment of calcified lesions, stents are frequently used in conjunction with PTCA or atherectomy to decrease the risk of restenosis. Extra care should be taken in deploying stents in lesions where incomplete expansion occurs following pre-dilation, as incomplete expansion of a target lesion will increase the likelihood of restenosis. Stents should be deployed only after ensuring full balloon expansion.

2011 ACCF/AHA/SCAI Guidelines for Percutaneous Coronary Intervention (DO NOT EDIT)[8]

Calcified Lesions (DO NOT EDIT)[8]

Class IIa
"1. Rotational atherectomy is reasonable for fibrotic or heavily calcified lesions that might not be crossed by a balloon catheter or adequately dilated before stent implantation.[9][10][11] (Level of Evidence: C)"

References

  1. 1.0 1.1 Mintz GS, Popma JJ, Pichard AD; et al. (1995). "Patterns of calcification in coronary artery disease. A statistical analysis of intravascular ultrasound and coronary angiography in 1155 lesions". Circulation. 91 (7): 1959–65. PMID 7895353. 
  2. 2.0 2.1 Castagna MT, Mintz GS, Ohlmann P; et al. (2005). "Incidence, location, magnitude, and clinical correlates of saphenous vein graft calcification: an intravascular ultrasound and angiographic study". Circulation. 111 (9): 1148–52. PMID 15723972. doi:10.1161/01.CIR.0000157160.69812.55. 
  3. Vavuranakis M, Toutouzas K, Stefanadis C, Chrisohou C, Markou D, Toutouzas P (2001). "Stent deployment in calcified lesions: can we overcome calcific restraint with high-pressure balloon inflations?". Catheter Cardiovasc Interv. 52 (2): 164–72. PMID 11170322. 
  4. Wilensky RL, Selzer F, Johnston J; et al. (2002). "Relation of percutaneous coronary intervention of complex lesions to clinical outcomes (from the NHLBI Dynamic Registry)". Am. J. Cardiol. 90 (3): 216–21. PMID 12127606. 
  5. Moussa I, Ellis SG, Jones M; et al. (2005). "Impact of coronary culprit lesion calcium in patients undergoing paclitaxel-eluting stent implantation (a TAXUS-IV sub study)". Am. J. Cardiol. 96 (9): 1242–7. PMID 16253590. doi:10.1016/j.amjcard.2005.06.064. 
  6. http://www.lvhn.org/lvh/Your_LVH/Health_Care_Services/Heart_Care_MIMS/Most_Advanced_Treatments%7C3487
  7. Cook SL, Eigler NL, Shefer A, Goldenberg T, Forrester JS, Litvack F (1991). "Percutaneous excimer laser coronary angioplasty of lesions not ideal for balloon angioplasty". Circulation. 84 (2): 632–43. PMID 1860207. 
  8. 8.0 8.1 Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Nallamothu BK, Ting HH (2011). "2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention: Executive Summary A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions" (PDF). Journal of the American College of Cardiology. 58 (24): 2550–83. PMID 22070837. doi:10.1016/j.jacc.2011.08.006. Retrieved 2011-12-08. 
  9. Moussa I, Di Mario C, Moses J, Reimers B, Di Francesco L, Martini G, Tobis J, Colombo A (1997). "Coronary stenting after rotational atherectomy in calcified and complex lesions. Angiographic and clinical follow-up results". Circulation. 96 (1): 128–36. PMID 9236427. Retrieved 2011-12-15. 
  10. Vaquerizo B, Serra A, Miranda F, Triano JL, Sierra G, Delgado G, Puentes A, Mojal S, Brugera J (2010). "Aggressive plaque modification with rotational atherectomy and/or cutting balloon before drug-eluting stent implantation for the treatment of calcified coronary lesions". Journal of Interventional Cardiology. 23 (3): 240–8. PMID 20636844. doi:10.1111/j.1540-8183.2010.00547.x. Retrieved 2011-12-15. 
  11. Brogan WC, Popma JJ, Pichard AD, Satler LF, Kent KM, Mintz GS, Leon MB (1993). "Rotational coronary atherectomy after unsuccessful coronary balloon angioplasty". The American Journal of Cardiology. 71 (10): 794–8. PMID 8456756. 



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