PB28

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PD28
250px
IUPAC name 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetra-

hydronaphthalen-1-yl)propyl]piperazine

Other names PD28
Identifiers
CAS number
SMILES COc1c(CCCC2CCCN3CCN(C4CCCCC4)CC3)c2ccc1
Properties
Molecular formula C24H38N2O
Molar mass 370.57 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

PB28[1] is an agonist of the sigma-2 receptor.[2][3]

It is derived from cyclohexylpiperazine.

References

  1. Berardi F, Colabufo NA, Giudice G, Perrone R, Tortorella V, Govoni S, Lucchi L (1996). "New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives". J. Med. Chem. 39 (1): 176–82. PMID 8568804. doi:10.1021/jm950409c. 
  2. Cassano G, Gasparre G, Contino M, Niso M, Berardi F, Perrone R, Colabufo NA (2006). "The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells". Cell Calcium. 40 (1): 23–8. PMID 16687172. doi:10.1016/j.ceca.2006.03.004. 
  3. Azzariti A, Colabufo NA, Berardi F, Porcelli L, Niso M, Simone GM, Perrone R, Paradiso A (2006). "Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer". Mol. Cancer Ther. 5 (7): 1807–16. PMID 16891467. doi:10.1158/1535-7163.MCT-05-0402. 

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