p16INK4a

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cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Identifiers
SymbolCDKN2A
Alt. symbolsCDKN2, MLM
Entrez1029
HUGO1787
OMIM600160
RefSeqNM_000077
UniProtP42771
Other data
LocusChr. 9 p21

p16INK4a is a major product of the CDKN2A locus. Its alternate reading frame product is p14ARF. p16INK4a regulates the cell cycle by binding and deactivating various cyclin-CDKcomplexes.

A study published in 2007 in the New England Journal of medicine established that there is a strong association between polymorphisms on chromosome 9p21.3 (SNP, rs1333049) and coronary artery disease. This region codes for the INK4 proteins p16INK4a and p15INK4b. The corresponding genes are CDKN2A and CDKN2B. The proteins may inhibit cell growth induced by Transforming Growth Factor-beta.

External links

  • "Scientists study mammalian aging" at United Press International
  • Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE (2006). "p16INK4a induces an age-dependent decline in islet regenerative potential". Nature. 443 (7110): 453–7. PMID 16957737.
  • NEJM 2007 Genomewide Association Analysis of Coronary Artery Disease





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