P-type ATPase

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1wpg opm.gif
Calcium ATPase, E2-Pi state
Identifiers
SymbolE1-E2_ATPase
PfamPF00122
InterProIPR008250
PROSITEPDOC00139
SCOP1eul
SUPERFAMILY1eul
OPM superfamily22
OPM protein1wpg

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P-type (or E1-E2-type) ATPases constitute a superfamily of cation transport enzymes, present both in prokaryota and eukaryota, whose members mediate membrane flux of all common biologically relevant cations[1]. The ATPases, that form an aspartyl phosphate intermediate in the course of ATP hydrolysis, can be divided into 4 major groups[2]:

  • (1) Ca2+-transporting ATPases;
  • (2) Na+/K+- and gastric H+/K+-transporting ATPases;
  • (3) Plasma membrane H+-transporting ATPases (proton pumps) of plants, fungi and lower eukaryotes; and
  • (4) all bacterial P-type ATPases, except the Mg2+-ATPase of Salmonella typhimurium, which is more similar to the eukaryotic sequences.

Human proteins containing this domain

See also

References

  1. Maguire ME, Smith DL, Tao T (1993). "Membrane topology of a P-type ATPase. The MgtB magnesium transport protein of Salmonella typhimurium". J. Biol. Chem. 268 (30): 22469–22479. PMID 8226755.
  2. Fagan MJ, Saier Jr MH (1994). "P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees". J. Mol. Evol. 38 (1): 57–99. PMID 8151716.



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