Other red cell antigens

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


In addition to the defined Human blood group systems, there are erythrocyte antigens which do not meet the definition of a blood group system. Most of these are either nearly universal in human blood or extremely rare and are rarely significant in a clinical setting. Reagents to test for these antigens are difficult to find and many cannot be purchased commercially.

Blood Group Collections

These three groups are antigens with shared characteristics but do not meet the ISBT definition of a human blood group system. Further research may identify them as blood group systems.

Cost

The Knops blood group system was formerly part of this collection. All that remains are the Csa and Csb antigens. Csa is a very high frequency (>98%) antigen and Csb is not uncommon (~34%).

Er

The Er collection includes one high incidence (>99%) antigen, Era and one (<1%) rare antigen, Erb.

Vel

The Vel collection includes the high incidence Vel and ABTI antigens. Antibodies to Vel have been implicated in transfusion reactions.

Other high-incidence antigens

These antigens are almost universally present on human red cells, but their absence has been noted in some individuals and some have been associated with transfusion reactions or other problems. Finding compatible units for transfusion to a patient that lacks one of these antigens is a major challenge and some countries maintain rare donor registries specifically for that purpose.

  • Lan antigen: anti-Lan is IgG and has been associated with transfusion reactions. A weaker variant of the antigen has also been reported.
  • Ata Antigen: only found in people of African descent. Associated with hemolytic transfusion reactions but not hemolytic disease of the newborn.
  • Jra Antigen: mostly found in Japan. Not associated with acute transfusion reactions.
  • AnWj Antigen: the receptor for Haemophilus influenzae. Implicated in severe hemolytic transfusion reactions.
  • Sda Antigen: This antigen is present on cells other than red cells and is less frequent but still very common. It may be associated with transfusion reactions, but not hemolytic disease of the newborn.

Other low incidence antigens

These antigens are extremely rare and are of little concern in selecting compatible units for transfusion. They may be implicated in rare cases of hemolytic disease of the newborn, however.

  • Batty (By)
  • Biles (Bi)
  • Box (Bxa)
  • Christiansen (Chra)
  • HJK
  • HOFM
  • JFV
  • JONES
  • Jensen (Jea)
  • Katagiri (Kg)
  • Livesay (Lia)
  • Milne
  • Oldeide (Ola)
  • Peters (Pta)
  • Rasmussen (RASM)
  • Reid (Rea)
  • REIT
  • SARA
  • Torkildsen (Toa)
  • Bg (Bennett-Goodspeed): These are actually Human Leukocyte Antigens that cause confusing results on serological tests of erythrocytes.

References

  • Mark E. Brecher, Editor (2005), AABB Technical Manual, fifteenth edition, Bethesda, MD: AABB, ISBN 1-56935-19607, p. 355

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