Obidoxime

Jump to: navigation, search
Obidoxime
Obidoxime.png
Clinical data
ATC code
Pharmacokinetic data
ExcretionRenal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC14H16N4O3+2
Molar mass288.302 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Obidoxime

Articles

Most recent articles on Obidoxime

Most cited articles on Obidoxime

Review articles on Obidoxime

Articles on Obidoxime in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Obidoxime

Images of Obidoxime

Photos of Obidoxime

Podcasts & MP3s on Obidoxime

Videos on Obidoxime

Evidence Based Medicine

Cochrane Collaboration on Obidoxime

Bandolier on Obidoxime

TRIP on Obidoxime

Clinical Trials

Ongoing Trials on Obidoxime at Clinical Trials.gov

Trial results on Obidoxime

Clinical Trials on Obidoxime at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Obidoxime

NICE Guidance on Obidoxime

NHS PRODIGY Guidance

FDA on Obidoxime

CDC on Obidoxime

Books

Books on Obidoxime

News

Obidoxime in the news

Be alerted to news on Obidoxime

News trends on Obidoxime

Commentary

Blogs on Obidoxime

Definitions

Definitions of Obidoxime

Patient Resources / Community

Patient resources on Obidoxime

Discussion groups on Obidoxime

Patient Handouts on Obidoxime

Directions to Hospitals Treating Obidoxime

Risk calculators and risk factors for Obidoxime

Healthcare Provider Resources

Symptoms of Obidoxime

Causes & Risk Factors for Obidoxime

Diagnostic studies for Obidoxime

Treatment of Obidoxime

Continuing Medical Education (CME)

CME Programs on Obidoxime

International

Obidoxime en Espanol

Obidoxime en Francais

Business

Obidoxime in the Marketplace

Patents on Obidoxime

Experimental / Informatics

List of terms related to Obidoxime

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Obidoxime is a member of the oxime family used to treat nerve gas poisoning. Oximes are drugs known for their ability to reverse the binding of organophosphorus compounds to the enzyme acetylcholinesterase (AChE).[1]

AChE is an enzyme that removes acetylcholine from the synapse after it creates the required stimulation on the next nerve cell. If it gets inhibited, acetylcholine is not removed after the stimulation and multiple stimulations are made, resulting in muscle contractions and paralysis.

Organophosphates (such as nerve gases) are well-known inhibitors of AChE. They bind to a specific place on the enzyme and prevent it from functioning normally by changing the OH group on the serine residue and by protonating (quaternary nitrogen, R4N+) the nearby nitrogen atom located in the histidine residue.

Function

Oximes such as obidoxime, pralidoxime and asoxime (HI-6) are used to restore enzyme functionality. They have greater affinity for the organic phosphate residue than the enzyme and they remove the phosphate group, restore the OH to serine and turn nitrogen from histidine back into its R3N form (tertiary nitrogen). This results in full enzyme recovery and the phosphate-oxime compound is eliminated from the organism via urine.

Side effects

Oximes like these do have side effects and they include liver damage, kidney damage, nausea, vomiting, but they are very efficient antidotes to nerve gas poisoning. Usually treatment of poisoning includes the use of atropine, which can slow down the action of the poison, giving more time to apply the oxime.

References

  1. Jokanović M, Prostran M (2009). "Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds". Curr. Med. Chem. 16 (17): 2177–88. doi:10.2174/092986709788612729. PMID 19519385.

Linked-in.jpg