Nucleoside-phosphate kinase

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In enzymology, a nucleoside-phosphate kinase (EC 2.7.4.4) is an enzyme that catalyzes the chemical reaction

ATP + nucleoside phosphate ADP + nucleoside diphosphate

Thus, the two substrates of this enzyme are ATP and nucleoside phosphate, whereas its two products are ADP and nucleoside diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:nucleoside-phosphate phosphotransferase. This enzyme is also called NMP-kinase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BND, 2BNE, and 2BNF.

References

  • IUBMB entry for 2.7.4.4
  • BRENDA references for 2.7.4.4 (Recommended.)
  • PubMed references for 2.7.4.4
  • PubMed Central references for 2.7.4.4
  • Google Scholar references for 2.7.4.4
  • AYENGAR P, GIBSON DM, SANADI DR (1956). "Transphosphorylations between nucleoside phosphates". Biochim. Biophys. Acta. 21: 86&ndash, 91. PMID 13363863.
  • HEPPEL LA, STROMINGER JL, MAXWELL ES (1959). "Nucleoside monophosphate kinases. II. Transphosphorylation betweeen adenosine monophosphate and nucleoside triphosphates". Biochim. Biophys. Acta. 32: 422&ndash, 30. PMID 14401179.
  • LIEBERMAN I, KORNBERG A, SIMMS ES (1955). "Enzymatic synthesis of nucleoside diphosphates and triphosphates". J. Biol. Chem. 215: 429&ndash, 40. PMID 14392176.
  • Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 139-149.

External links

The CAS registry number for this enzyme class is 9026-50-0.

Gene Ontology (GO) codes


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