Non-specific serine/threonine protein kinase

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In enzymology, a non-specific serine/threonine protein kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + a protein ADP + a phosphoprotein

Thus, the two substrates of this enzyme are ATP and protein, whereas its two products are ADP and phosphoprotein.

This enzyme belongs to the family of transferases, specifically those transferring phosphates to the oxygen atom of a serine or threonine sidechain in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:protein phosphotransferase (non-specific). Other names in common use include A-kinase, AP50 kinase, ATP-protein transphosphorylase, calcium-dependent protein kinase C, calcium/phospholipid-dependent protein kinase, cAMP-dependent protein kinase, cAMP-dependent protein kinase A, casein kinase, casein kinase (phosphorylating), casein kinase 2, casein kinase I, casein kinase II, cGMP-dependent protein kinase, CK-2, CKI, CKII, cyclic AMP-dependent protein kinase, cyclic AMP-dependent protein kinase A, cyclic monophosphate-dependent protein kinase, cyclic nucleotide-dependent protein kinase, cyclin-dependent kinase, cytidine 3',5'-cyclic monophosphate-responsive protein kinase, dsk1, glycogen synthase a kinase, glycogen synthase kinase, HIPK2, Hpr kinase, hydroxyalkyl-protein kinase, hydroxyalkyl-protein kinase, M phase-specific cdc2 kinase, mitogen-activated S6 kinase, p82 kinase, phosphorylase b kinase kinase, PKA, protein glutamyl kinase, protein kinase (phosphorylating), protein kinase A, protein kinase CK2, protein kinase p58, protein phosphokinase, protein serine kinase, protein serine-threonine kinase, protein-aspartyl kinase, protein-cysteine kinase, protein-serine kinase, Prp4 protein kinase, Raf kinase, Raf-1, ribosomal protein S6 kinase II, ribosomal S6 protein kinase, serine kinase, serine protein kinase, serine-specific protein kinase, serine(threonine) protein kinase, serine/threonine protein kinase, STK32, T-antigen kinase, threonine-specific protein kinase, twitchin kinase, type-2 casein kinase, betaIIPKC, epsilon PKC, Wee 1-like kinase, Wee-kinase, and WEE1Hu. This enzyme participates in 55 metabolic pathways: neurodegenerative disorders, ppar signaling pathway, mapk signaling pathway, erbb signaling pathway, cell cycle, cell cycle - yeast, p53 signaling pathway, regulation of autophagy, mtor signaling pathway, apoptosis, wnt signaling pathway, dorso-ventral axis formation, hedgehog signaling pathway, tgf-beta signaling pathway, axon guidance, vegf signaling pathway, focal adhesion, adherens junction, tight junction, gap junction, toll-like receptor signaling pathway, jak-stat signaling pathway, natural killer cell mediated cytotoxicity, t cell receptor signaling pathway, b cell receptor signaling pathway, fc epsilon ri signaling pathway, leukocyte transendothelial migration, circadian rhythm, long-term potentiation, long-term depression, regulation of actin cytoskeleton, insulin signaling pathway, gnrh signaling pathway, progesterone-mediated oocyte maturation, melanogenesis, adipocytokine signaling pathway, parkinson's disease, epithelial cell signaling in helicobacter pylori, [[]], pathogenic escherichia coli infection - ehec, pathogenic escherichia coli infection - epec, colorectal cancer, renal cell carcinoma, pancreatic cancer, endometrial cancer, glioma, prostate cancer, thyroid cancer, basal cell carcinoma, and melanoma.

Structural studies

As of late 2007, 91 structures have been solved for this class of enzymes, with PDB accession codes 1MRY, 1UL7, 1WAK, 2CKE, 2CMW, 2CN5, 2CN8, 2DWB, 2EHB, 2H34, 2H6D, 2H9V, 2HAK, 2HOG, 2HW6, 2HW7, 2HXL, 2HXQ, 2HY0, 2HY8, 2I3S, 2ILL, 2IWI, 2IZR, 2IZS, 2IZT, 2IZU, 2J0I, 2J2I, 2J4Z, 2J50, 2J51, 2J7T, 2J8H, 2J8O, 2J90, 2JBO, 2JBP, 2JD5, 2JDO, 2JDR, 2JFL, 2JFM, 2JII, 2JO8, 2NP8, 2NRU, 2NRY, 2NZI, 2O3P, 2O63, 2O64, 2O65, 2OBJ, 2OI4, 2OIB, 2OIC, 2OID, 2OKR, 2ONL, 2OOX, 2OOY, 2OV2, 2OXD, 2OXX, 2OXY, 2OZA, 2P3G, 2PE0, 2PE1, 2PE2, 2PVR, 2PZI, 2PZY, 2Q0N, 2QKW, 2QLV, 2QME, 2QNJ, 2UUE, 2UV2, 2UVM, 2UW9, 2UZR, 2UZS, 2V3S, 2V62, 2V8Q, 2V92, 2V9J, and 2YWP.


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