Non-alcoholic fatty liver disease historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S[2]

Overview

NAFLD/NASH was first described as a medical entity in a 1980. Though its histological capabilities had lengthy been recognized , the time period non-alcoholic steatohepatitis (NASH) became first used by Ludwig et al. as recently as 1980 .Ludwig et al. described ‘‘the pathological and medical features of non-alcoholic disease of the liver related with the pathological features maximum generally seen inside the alcoholic liver disorder itself.

Historical Perspective

  • In 1980, NAFLD was introduced as a new concept in medical history.[1][2][3][4]
  • The association between obesity and NAFLD was made during 1979 by Adler & Schaffner by extending the clinical picture of NASH.
  • In an intensive literature seek of 41 papers.published before 1984, reporting on 1515 morbidly overweight sufferers, Andersen & Gluud reported excess fat in 80%,‘‘parenchymal necrosis’’ in 5–63%, fibrosis in 29% and cirrhosis in 3%.[5]

References

  1. Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc. 1980;55:434-438. PMID 7382552.
  2. Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J (2017). "Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies". J Clin Transl Hepatol. 5 (1): 67–75. PMC 5411359Freely accessible. PMID 28507929. doi:10.14218/JCTH.2016.00061. 
  3. Vizuete J, Camero A, Malakouti M, Garapati K, Gutierrez J (2017). "Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies". J Clin Transl Hepatol. 5 (1): 67–75. PMC 5411359Freely accessible. PMID 28507929. doi:10.14218/JCTH.2016.00061. 
  4. Day, CP. Non-alcoholic steatohepatitis (NASH): where are we now and where are we going? Gut. 2002 May; 50(5): 585–588.
  5. "ac-els-cdn-com.ezp-prod1.hul.harvard.edu" (PDF). 

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