Nodular sclerosis

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Nodular sclerosis
ICD-10 C81.1
ICD-9 201.5
ICD-O: 9663/3-9667/3

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Nodular sclerosis (or "NSHL") is a form of Hodgkin's lymphoma which is the most common subtype of HL in developed countries. It usually affects females more than males and has a median age of onset at ~28 years. It is composed of large tumor nodules with lacunar Reed-Sternberg cell (RS cells) surrounded by fibrotic collagen bands.

The British National Lymphoma Investigation further categorized NSHL based upon Reed-Sternberg cells into "nodular sclerosis type I" (NS I) and "nodular sclerosis type II" (NS II), with the first subtype responding better to treatment. [1]

Reference

  1. Mauch, Peter (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. p. 107. ISBN 0-7817-1502-4. Unknown parameter |coauthors= ignored (help)

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