Nigericin

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Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464.

Nigericin acts as an H+, K+, Pb++ ionophore. It most commonly is an antiporter of H+ and K+.

In the past Nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions. Nigericin exhibits anti-HIV activity.

Properties

  • CAS number: 28643-80-3
  • Merck index: 12, 6633
  • Molecular weight: 747
  • Formula C40H67O11Na

The properties are copied from a manufacturer's Nigericin product page]

External references





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