Neutropenia

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Neutropenia Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Neutropenia from other Diseases

Epidemiology and Demographics

Risk Factors

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Natural History, Complications and Prognosis

Diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Aric Hall, M.D. Beth Israel Deaconess Medical Center, Boston, MA[2] Associate Editor(s)-in-Chief: Daniel A. Gerber, M.D. [3], Faizan Sheraz, M.D. [4]

Synonyms and Keywords: Agranulocytosis, agranulosis, benign familial neutropenia, chronic benign neutropenia, cyclic neutropenia, CN, cyclic hematopoiesis, granulocytopenia, granulopenia, human cyclic neutropenia, neutropaenia, neutrophilic leukopenia, neutrophilic leukocytopenia, neutrophilic leucopenia, neutrophilic leucocytopenia

Neutropenia is defined absolute neutrophil count < 1.5 x 109/L.

Agranulocytosis is defined as severe neutropenia < 0.5 x 109/L.

Although agranulocytosis and granulocytopenia should include reduced numbers of all granulocytes (either neutrophils, eosinophils, or basophils), the majority of cases of granulocytopenia are actually neutropenia since neutrophils constitute the majority of leukocytes; the term granulocytopenia almost always refers to deficient neutrophils. To read about eosinophilic leukopenia and basophilic leukopenia, click here.

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Neutropenia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies


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