Neuronal calcium sensor

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Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.[1]

Members of NCS family

- Calsenilin or DREAM/KChIP-3 (downstream regulatory element antagonist modulator/potassium channel interacting protein) - Calsenilin like protein (KChIP-4)


  1. Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.