Nalfurafine

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Nalfurafine
Nalfurafine.png
Clinical data
SynonymsTRK-820
AHFS/Drugs.comInternational Drug Names
Routes of
administration
intravenous
ATC code
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC28H32N2O5
Molar mass476.564 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Nalfurafine (INN and USAN;[1] also known as AC-820, TRK-820; trade name Remitch) is a κ-opioid receptor agonist marketed as a treatment for uremic pruritus in people undergoing hemodialysis.[2]

As of January 2010, it is also being investigated for the treatment of pruritus in patients with chronic liver disease.[3]

References

  1. Statement on a Nonproprietary Name adopted by the USAN Council
  2. "AC-820". Acologix. 2009.
  3. Clinical trial number NCT00638495 for "Phase II Study of TRK-820 Soft Capsules — Intractable Pruritus in Patients With Chronic Liver Disease" at ClinicalTrials.gov

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