NK1 receptor antagonist

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Neurokinin NK1 antagonists are a novel class of medications that possesses unique antidepressant[1], anxiolytic[2], and antiemetic properties.

The NK2 and NK3 receptors are also targets for novel classes of medications, and also show prominent antidepressive and anxiolytic effects.[3]

See also

References

  1. Varty GB, Cohen-Williams ME, Hunter JC (2003). "The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension test". Behavioural pharmacology. 14 (1): 87–95. PMID 12576885. doi:10.1097/01.fbp.0000055962.09493.e9. 
  2. Varty GB, Cohen-Williams ME, Morgan CA; et al. (2002). "The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists". Neuropsychopharmacology. 27 (3): 371–9. PMID 12225694. doi:10.1016/S0893-133X(02)00313-5. 
  3. Salomé N, Stemmelin J, Cohen C, Griebel G (2006). "Selective blockade of NK2 or NK3 receptors produces anxiolytic- and antidepressant-like effects in gerbils". Pharmacol. Biochem. Behav. 83 (4): 533–9. PMID 16624395. doi:10.1016/j.pbb.2006.03.013. 



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