N-acylglucosamine-6-phosphate 2-epimerase

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In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.9) is an enzyme that catalyzes the chemical reaction

N-acyl-D-glucosamine 6-phosphate N-acyl-D-mannosamine 6-phosphate

Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.

References

  • IUBMB entry for 5.1.3.9
  • BRENDA references for 5.1.3.9 (Recommended.)
  • PubMed references for 5.1.3.9
  • PubMed Central references for 5.1.3.9
  • Google Scholar references for 5.1.3.9
  • Ghosh S and Roseman S (1965). "The sialic acids. IV. N-Acyl-D-glucosamine 6-phosphate 2-epimerase". J. Biol. Chem. 240: 1525&ndash, 1530.

External links

The CAS registry number for this enzyme class is 37318-35-7.

Gene Ontology (GO) codes



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