N-Phenethyl-14-ethoxymetopon

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N-Phenethyl-14-ethoxymetopon
N-Phenethyl-14-ethoxymetopon.svg
Identifiers
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC27H31NO4
Molar mass433.538 g/mol
3D model (JSmol)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

N-Phenethyl-14-ethoxymetopon is a drug which is a derivative of metopon. It is a potent analgesic, around 60 times stronger than morphine, but produces significantly less constipation.[1]

N-Phenethyl-14-ethoxymetopon acts as an agonist at both μ- and δ-opioid receptors, with a Ki of 0.16nM at μ and 3.14nM at δ.[2]

References

  1. Ananthan S. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS Journal. 2006 Mar 10;8(1):E118-25. PMID 16584118
  2. Lattanzi R, Spetea M, Schüllner F, Rief SB, Krassnig R, Negri L, Schmidhammer H. Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities. Journal of Medicinal Chemistry. 2005 May 5;48(9):3372-8. PMID 15857143




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