Myxomatous degeneration

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overivew

Myxomatous degeneration refers to a pathological weakening of connective tissue. The term is most often used in the context of mitral valve prolapse, which is known more technically as "myxomatous degeneration of the mitral valve." [1] It can also be used in refernce to degeneration of the aortic valve.

Pathophysiology

The degeneration occurs in conjunction with an accumulation of dermatan sulfate, a glycosaminoglycan, within the connective tissue matrix of the valve. The exact mechanism is unknown.

In many cases, the degeneration is limited to the mitral valve and follows a benign course. When associated with systemic diseases, like Marfan syndrome, the degeneration is more extensive and involves other heart valves. The valves can become sufficiently distorted to cause insufficiency and regurgitation.

References

  1. Cotran RS, Kumar V, Fausto N, Nelso F, Robbins SL, Abbas AK. Robbins and Cotran pathologic basis of disease. 7th ed. Elsevier Saunders. St. Louis, Mo 2005 ISBN 0-7216-0187-1


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| group5 = Clinical Trials Involving Myxomatous degeneration | list5 = Ongoing Trials on Myxomatous degeneration at Clinical Trials.govTrial results on Myxomatous degenerationClinical Trials on Myxomatous degeneration at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Myxomatous degeneration | list6 = US National Guidelines Clearinghouse on Myxomatous degenerationNICE Guidance on Myxomatous degenerationNHS PRODIGY GuidanceFDA on Myxomatous degenerationCDC on Myxomatous degeneration


| group7 = Textbook Information on Myxomatous degeneration | list7 = Books and Textbook Information on Myxomatous degeneration


| group8 = Pharmacology Resources on Myxomatous degeneration | list8 = AND (Dose)}} Dosing of Myxomatous degenerationAND (drug interactions)}} Drug interactions with Myxomatous degenerationAND (side effects)}} Side effects of Myxomatous degenerationAND (Allergy)}} Allergic reactions to Myxomatous degenerationAND (overdose)}} Overdose information on Myxomatous degenerationAND (carcinogenicity)}} Carcinogenicity information on Myxomatous degenerationAND (pregnancy)}} Myxomatous degeneration in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Myxomatous degeneration


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Myxomatous degeneration | list9 = AND (pharmacogenomics)}} Genetics of Myxomatous degenerationAND (pharmacogenomics)}} Pharmacogenomics of Myxomatous degenerationAND (proteomics)}} Proteomics of Myxomatous degeneration


| group10 = Newstories on Myxomatous degeneration | list10 = Myxomatous degeneration in the newsBe alerted to news on Myxomatous degenerationNews trends on Myxomatous degeneration


| group11 = Commentary on Myxomatous degeneration | list11 = Blogs on Myxomatous degeneration

| group12 = Patient Resources on Myxomatous degeneration | list12 = Patient resources on Myxomatous degenerationDiscussion groups on Myxomatous degenerationPatient Handouts on Myxomatous degenerationDirections to Hospitals Treating Myxomatous degenerationRisk calculators and risk factors for Myxomatous degeneration


| group13 = Healthcare Provider Resources on Myxomatous degeneration | list13 = Symptoms of Myxomatous degenerationCauses & Risk Factors for Myxomatous degenerationDiagnostic studies for Myxomatous degenerationTreatment of Myxomatous degeneration

| group14 = Continuing Medical Education (CME) Programs on Myxomatous degeneration | list14 = CME Programs on Myxomatous degeneration

| group15 = International Resources on Myxomatous degeneration | list15 = Myxomatous degeneration en EspanolMyxomatous degeneration en Francais

| group16 = Business Resources on Myxomatous degeneration | list16 = Myxomatous degeneration in the MarketplacePatents on Myxomatous degeneration

| group17 = Informatics Resources on Myxomatous degeneration | list17 = List of terms related to Myxomatous degeneration


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