Myeloproliferative neoplasm MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]

Overview

Brain MRI is helpful in the detection of thrombotic events, such as ischemic stroke, in patients with myeloproliferative neoplasm. Abdominal MRI is helpful in the detection of mesenteric thrombosis in patients with myeloproliferative neoplasm.

MRI

MRI may be helpful in the detection of anatomic abnormalities in patients with myeloproliferative neoplasm. However, MRI is an expensive test and should be reserved for patients in whom CT or ultrasound are nondiagnostic.

  • Ischemia stroke: MRI of the brain is the most sensitive test for assessment of cerebral vascular abnormalities associated with myeloproliferative neoplasm. Patients with myeloproliferative neoplasm frequently develop thrombotic complications such as ischemic stroke, especially for patients who are at high risk for thrombotic events, such as patients above the age of 60 and with a JAK2 mutation.[1][2]
  • Mesenteric thrombosis: MRI of the abdomen is the most sensitive test for assessment of thrombosis of the mesenteric vasculature, such as the portal vein, splenic vein, superior mesenteric vein, or inferior mesenteric vein.

References

  1. Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
  2. Koennecke HC, Bernarding J (2001). "Diffusion-weighted magnetic resonance imaging in two patients with polycythemia rubra vera and early ischemic stroke". Eur J Neurol. 8 (3): 273–7. PMID 11328338.

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